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Here’s How the Ebola Vaccine Trial Is Doing

TIME MAGAZINE By Alexandra Sifferlin                          Nov. 25, 2014
 By  Alexandra Sifferlin                       

Scientists are scurrying to get their Ebola vaccines through the necessary safety trials before they can be used widely. That includes the University of Maryland School of Medicine, which recently kicked off the latest step in their research: figuring out the appropriate dosing for the vaccine that’s both effective and safe.

The University of Maryland is one of a handful of institutions involved in the testing of an experimental but promising vaccine developed by the National Institutes of Health’s Vaccine Research Center (VRC) and GlaxoSmithKline (GSK). The hope is that the vaccine will pass through early trials needed by end of December so that the World Health Organization (WHO) and a panel of outside experts can decide whether to move on to a large efficacy trial, which would mean vaccinating a lot of people in West Africa to see how well it works.

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The US Is Stockpiling Ebola Survivors’ Plasma to Treat Future Patients

                                                                                                    Getty Images

WIRED                 BY Katie M. Palmer                                                    Nov. 24, 214

The FDA announced Friday that it would start developing a stockpile of blood plasma from Ebola survivors, treated with a pathogen inactivation system that’s never been used before in the United States.

So far, the US has had some amazing success in curing Ebola, possibly thanks to experimental plasma treatments. Drawn from survivors, the stuff comes enriched in antibodies that could help to fight off the disease—but it also has the potential to carry other diseases, like malaria, that are common in west Africa where Ebola is raging. The new system will kill off any extra contaminants that may be lurking in this potentially live-saving serum.

It’s the same one, Cerus Corporation’s Intercept system, that will be used in a Gates Foundation-funded study of Ebola treatments in West Africa. The pathogen-killing molecule at the heart of the system is amotosalen, part of a class of three-ringed molecules called psoralens....

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Ebola Mappers Track Epidemic in Real Time 
 
 


NBC NEWS       By Nikita Japra                                                                                     Nov. 23, 2014
In a darkened Boston conference room, staring at projections from a laptop, John Brownstein is far from the front lines of the fight against Ebola. But the epidemiologist’s work may help change the course of the epidemic.

The disease forecaster and his team are combing through news reports, tweets and Facebook posts to anticipate the disease’s next move — and help those on the ground head it off before the crisis grows....

Brownstein’s HealthMap scours social media and local news from around the globe to locate potential hot spots and display them in an interactive map. In the past, HealthMap has spotted outbreaks ranging from H1N1 swine flu to Dengue fever. Today, the team is building interactive maps that can guide the response to the worst Ebola outbreak ever recorded.

While official numbers from government agencies can take precious time to confirm, Brownstein’s team looks to more immediate, unconventional sources to help target the right communities at the right time.

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The suit designed to come between NHS Ebola workers and death

THE TELEGRAPH     By Rosa  Silverman                                                                                      Nov.23, 2014

With its domed helmet, protective outer apron and thick boots, this is the kit National Health Service medics are depending on to save their lives as they fight Ebola in Africa.

More than 30 volunteers from the UK arrived in Sierra Leone today, prepared to join the effort to combat the deadly virus.

The medics, who came from across Britain and flew from London’s Heathrow airport on Saturday, were the first batch of NHS volunteers to be deployed by the Government after more than a thousand came forward to offer their services.

Among them are GPs, nurses, psychiatrists and emergency medicine consultants, all of whom will work in treatment centres built by British Army Royal Engineers and funded by the Department for International Development.

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An Ebola Clinic Figures Out A Way To Start Beating The Odds

NATIONAL PUBLIC RADIO                                                                                                        Nov. 21, 2014
by Nurith Aizenman

FREETOWN, Sierra Leone

Description of how the Hastings Ebola Treatment Center in Freetown, Sierra Leone is having success by having experienced nurses useIV's to counter the dehydration of Ebola patients.

Health workers are disinfected with a chlorine solution after treating patients at the Hastings Ebola Treatment Center in Freetown.

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http://www.npr.org/blogs/goatsandsoda/2014/11/21/365715575/an-ebola-clinic-figures-out-a-way-to-start-beating-the-odds

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First British volunteers fly to Sierra Leone to battle Ebola

THE ASSOCIATED PRESS                                Nov. 22, 2014

FREETOWN, Sierra Leone -- The first wave of volunteers from Britain's National Health Service arrived in Sierra Leone Saturday amid what the World Health Organization has described as an "intense" surge in cases.

A sign reading 'Kill Ebola Before Ebola Kill You', on a gate is mounted as part of the country's Ebola awareness campaign in the city of Freetown, Sierra Leone, Sept. 14, 2014. (AP / Michael Duff, File)

More than 30 NHS staffers, including general practitioners and nurses, were expected to stay in Freetown, the capital, for one week of training before moving to treatment centres across the country, Britain's Department for International Development said in a statement.

They join nearly 1,000 British soldiers, scientists and aid workers already in the country participating in the Ebola fight, International Development Secretary Justine Greening said.

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Researchers Develop Real-Time Monitoring for Ebola Outbreaks

VOICE OF AMERICA                                                                                                        Nov. 20, 2014
By Joe DeCapua
Knowing where the Ebola hot spots are in a country is crucial to getting an outbreak quickly under control. Many have criticized the initial slow response to the West Africa outbreak, saying it’s a big reason the virus quickly spread. Now, a German research center is developing a project to monitor Ebola and other outbreaks in real time.

Professor Gérard Krause said the new project – called EBOKON – uses real-time monitoring to better manage an outbreak.Krause is head of the Department of Epidemiology at the Helmholtz Center for Infection Research – and EBOKON project leader for the German Center for Infection Research....

He said, “This is an information technology tool that we are developing together with colleagues from Nigeria that will take care of all those management aspects.”

The EBOKON project calls for setting up a command center, so to speak, in the capital of affected countries. Then health workers would use cellphones to relay in real time information on suspected cases around the country.

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Gates Foundation, other donors launch study of Ebola drugs, survivors' blood, in Africa

ASSOCIATED PRESS                                                                                                  Nov. 18, 2014

A coalition of companies and aid groups announced plans Tuesday to test experimental drugs and collect blood plasma from Ebola survivors to treat new victims of the disease in West Africa.

This Nov. 7, 2014, photo shows the inside a mobile donation unit at the Raleigh-Durham International Airport in Raleigh, N.C. The unit was headed to Africa for use in a study of blood plasma treatment for Ebola patients. (AP Photo/Trevor Jenkins) (The Associated Press)

Plasma from survivors contains antibodies, substances the immune system makes to fight the virus. Several Ebola patients have received survivor plasma and recovered, but doctors say there is no way to know whether it really helps without a study like the one they are about to start within a month.

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Beating Ebola Means Drinking, Last Thing Patient Wants to Do

BLOOMBERG BUSINESSWEEK                                Nov. 17, 2014
by Jason Gale

The best medical advice for surviving Ebola right now might fit in one word: drink.

Dr. Fadipe Akinniyi Emmanuel, Ebola survivor, shows the daily dose of oral rehydration salts, or ORS, he and other survivors took to survive in Nigeria. Photographer: Andrew Esiebo/World Health Organization via Bloomberg

With targeted drugs and vaccines at least months away, doctors and public health experts are learning from Ebola survivors what simple steps helped them beat the infection. Turns out drinking 4 liters (1 gallon) or more of rehydration solution a day -- a challenge for anyone and especially those wracked by relentless bouts of vomiting -- is crucial. “When people are infected, they get dry as a crisp really quickly,” said Simon Mardel, an emergency room doctor advising the World Health Organization on Ebola in Sierra Leone. “Then the tragedy is that they don’t want to drink.”

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In Ebola fight, private foundations provide critical financial aid

Description of the way the CDC Foundation, the Allen Foundation and large donors are playing an important role in countering Ebola.

THE WASHINGTON POST                                                                                                          Nov. 17, 2014
By Ariana Eunjung Cha

"...The unpredictable nature of the Ebola virus has made the government’s partnerships with private donors critically important in the crisis response. Working outside the politically charged federal appropriations process and the sometimes sluggish bureaucracy, foundations and private individuals have been able to offer much-needed relief for those on the front lines...."

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http://www.washingtonpost.com/national/health-science/in-ebola-fight-private-foundations-provide-critical-financial-aid/2014/11/16/b57ec57e-6109-11e4-9f3a-7e28799e0549_story.html

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