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Merck-NewLink Ebola vaccine trial resumes at lower dose: Geneva hospital

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REUTERS                                                       Jan. 5, 2015

GENEVA --The clinical trial of an Ebola vaccine developed by Merck and NewLink resumed on Monday at a lower dose after a pause to assess complaints of joint pains in some volunteers, the University of Geneva hospital said.

The Geneva hospital announced on Dec. 11 that its vaccine trial had been suspended as a precautionary measure after four patients complained of joint pains. On Monday, the hospital said 10 of 59 volunteers who received the vaccine had felt pains in their joints "similar to rheumatism" after some two weeks, but these symptoms had disappeared rapidly without any treatment.

Swissmedic, the Swiss regulatory agency, and ethics and safety committees have approved the resumption of the trial at a lower dose, the hospital said in a statement.

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http://www.reuters.com/article/2015/01/05/us-health-ebola-vaccine-idUSKBN0KE0XP20150105
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Ebola survivors in west Africa to share stories via mobile app

REUTERS                                                            Jan. 4, 2015   

Ebola survivors in the three west African countries worst hit by the epidemic will share their stories through a mobile application to be launched on Monday, in a Unicef-backed campaign to inform and fight stigma around the disease.

...Although many people have survived the disease, they still face rejection and stigma from their communities, while the virus continues to spread due to lack of information and denial, according to the WHO and other health organisations.

The campaign, called #ISurvivedEbola, is funded by US philanthropist and co-founder of Microsoft Paul G Allen’s foundation which has committed $100m to fight the disease. Unicef, the UN children’s agency is collaborating in the project.

Survivors in Guinea, Sierra Leone and Liberia will be given smartphones and will document their stories and exchange tips on how to cope with it for a mobile app which will be available to the public, the backers said in a statement.

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Fight against Ebola requires district-by-district approach – head of UN response mission

UNITED NATIONS NEWS CENTRE                                                                                 Dec. 30, 2014

MONROVIA, Liberia --The outgoing head of the head of the United Nations Emergency Ebola Response Mission (UNMEER) said today that communities are going to play a big role in defeating the “nasty disease” in West Africa by stamping out outbreaks while they are small and not allowing them to become bigger.

The body of a suspected Ebola case in Sierra Leone is taken by an International Federation of Red Cross (IFRC) team on 24 December to the cemetery where it was buried in a dignified way. UN Photo/Martine Perret

“Ebola is a very nasty disease, and it’s going to present us with some very unpleasant surprises I fear going forward,” Anthony Banbury told UN Radio in Monrovia, Liberia. “And that’s why we really need to strengthen our capabilities.....”

...While acknowledging the difficulty in getting Ebola response workers to some of the remote areas, he emphasized the importance of a district by district strategy and said: “We really need to be present out in the districts....”

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Automated mobile phone service hopes to stop spread of Ebola in west Africa

THE GUARDIAN  by Mark Anderson                                                                    Dec. 30, 2014

People in rural areas of Liberia, Sierra Leone and Guinea battling Ebola could be helped by an automated phone service that offers advice about how to avoid contracting the virus.

Startup company Halt!Ebola is using “robocalling” to reach people where information hotlines are not being used.

The company is trying to acquire mobile phone numbers from the networks operating in these regions to enable them to make the calls. When people answer, an audio message with information and advice about the virus is played back.

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Ebola’s lessons, painfully learned at great cost in dollars and human lives

In-Depth report on lessons to be learned from the Ebola crisis

THE WASHINGTON POST by By Lena H. Sun, Brady Dennis and Joel Achenbach                            Dec. 29, 2014

A year after it began, the Ebola epidemic in West Africa continues to be unpredictable, forcing governments and aid groups to improvise strategies as they chase a virus that is unencumbered by borders or bureaucracy.

The people fighting Ebola are coming up with lists of lessons learned — not only for the current battle, which has killed more than 7,500 people and is far from over, but also for future outbreaks of deadly contagions.

Alice Jallabah, head of a bushmeat seller group, holds dried bushmeat in Monrovia. (Zoom Dosso/AFP/Getty Images)

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Where Ebola Has Closed Schools, A Radio Program Provides A Faint Signal Of Hope

NATIONAL PUBLIC RADIO by Ofeibea Quist-Arcton        Dec. 25, 2014

MONROVIA -- Working with UNICEF and another nonprofit, Talking Drum, in Monrovia, the capital of Liberia, the government aims to provide lessons to children across the country, hit by the Ebola outbreak. Most schools closed this past summer and will likely remain closed for months....

                            Florence Allen Jones, right, is part of the education ministry's classes-by-radio team.

The radio classes are broadcast on local stations, and on United Nations radio. The Education Ministry acknowledged that the broadcasts are not reaching nationwide. In any case, few children in Liberia's 15 counties have access to a radio, or even the batteries to power one. Wealthy parents have hired home tutors for their kids, but many other youngsters have taken to peddling petty goods, like trinkets or donuts, on the streets of Monrovia, to try to earn a little money for their families while schools are closed.

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Next in Ebola Plan: UN Teams to Study Lines of Transmission

REUTERS                                                              Dec. 24, 2014

ACCRA—Medical detective work will be the next big phase in the fight against Ebola when the United Nations deploys hundreds of health workers to identify chains of infection as the virus passes from person to person, top U.N. health workers said.
Health workers bury the body of a suspected Ebola victim at a cemetery in Freetown, Dec. 21, 2014.

The health teams will travel to each district and region of Guinea, Sierra Leone and Liberia, the three countries at the center of the epidemic, to trace who each infected person has potentially contacted.

The effort will run in parallel with measures to minimize the spread of infection, such as treating all Ebola patients in specialized centers and burying all victims safely.

But Phase Two of the plan is to contain the virus by understanding its lines of transmission, said World Health Organization Director-General Margaret Chan.

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Evaluation of the Benefits and Risks of Introducing Ebola Community Care Centers, Sierra Leone

     

CDC                                                                                                         Dec. 23, 2014    

Abstract of study on usefulness of Ebola community care centers to supplement larger  Ebola treatment centers.

 In some parts of western Africa, Ebola treatment centers (ETCs) have reached capacity. Unless capacity is rapidly scaled up, the chance to avoid a generalized Ebola epidemic will soon diminish. The World Health Organization and partners are considering additional Ebola patient care options, including community care centers (CCCs), small, lightly staffed units that could be used to isolate patients outside the home and get them into care sooner than otherwise possible.

Using a transmission model, we evaluated the benefits and risks of introducing CCCs into Sierra Leone’s Western Area, where most ETCs are at capacity. We found that use of CCCs could lead to a decline in cases, even if virus transmission occurs between CCC patients and the community. However, to prevent CCC amplification of the epidemic, the risk of Ebola virus–negative persons being exposed to virus within CCCs would have to be offset by a reduction in community transmission resulting from CCC use.

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Ebola raises profile of blood-based therapy

NATURE     by  Delcan Butler                                                                                        Dec. 23, 2014

With no drugs available to treat Ebola, eyes are turning to a therapy that had largely been relegated to the history books: transfusing patients with blood plasma donated by survivors, which contains antibodies against the virus.

Survivors of Ebola carry antibodies that might be used to save the lives of those infected with the virus. Michel du Cille/The Washington Post via Getty Images

Clinical trials of convalescent plasma therapy (CPT) have started in the past few weeks in Liberia, and are due to begin soon in Guinea and Sierra Leone. If the therapy saves lives, the approach could quickly be scaled up.

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On the Front Lines of Ebola’s Most Pressing Mystery

WIRED     by   Erika Check Hayden                                                                              Dec. 23, 2014

KENEMA, Sierra Leone—Mohammed Sankoh Yillah, an outreach worker, spent days in the Ebola ward caring for his sister, nurse Mbalu Fonnie. After Fonnie died in July, Yillah tested positive for the virus. He was transported to another hospital for treatment, but asked to come back to Kenema to die.

But Yillah survived.

Today Yillah sits with four colleagues in an office, discussing a new research project. The study is collecting information about survivors like him. The hope is that the study might help explain why he and others beat Ebola, while their friends and colleagues—Alex, Mbalu—did not.

Epidemiologist Lina Moses runs the meeting. Her colleagues back at Tulane University, she says, hope to analyze blood samples from survivors; she collected 29 such samples here in November. “What they want to know in the laboratory,” she says, “is what kind of antibodies Mohammed Yillah has that helped him to survive Ebola.”

 

                                                                             

 

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