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Ebola outbreak: Africa sets up $28.5m crisis fund

BBC                                                   Nov. 8 2014

Top African business leaders have established an emergency fund to help countries hit by the Ebola outbreak.

A pledging meeting in Addis Ababa, Ethiopia, raised $28.5m to deploy at least 1,000 health workers to Guinea, Sierra Leone and Liberia..... 

It is not clear why exactly the number of cases in Liberia has dipped - but it has been running an awareness campaign to advertise best health practices and install hand washing stations.

Speaking at the end of the Addis Abada meeting, African Union chairman Dlamini Zuma said the resources mobilised would be part of a longer term programme to deal with such outbreaks in the future.

The chairman of telecommunications giant Econet Wireless, Strive Masiyiwa, said that several companies had pledged money to the emergency fund - to be managed by the African Development Bank.

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http://www.bbc.com/news/world-africa-29967124

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Infection Secrets of Ebola Explained

By attacking the body's first responders, the virus cripples the immune system before it can mount an effective defense

Researchers often describe the battle between the Ebola virus and the humans it occasionally infects as a race—one that people win only if their immune systems manage to pull ahead before the virus destroys too many of their internal defenses. What they may not know is that the virus is a cheat.

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UN releases manual for safe Ebola burials

THE ASSOCIATED PRESS                                     NOV. 17, 2014

BERLIN  The World Health Organization has released a 17-page manual detailing how to safely bury people who have died from Ebola.

The U.N. agency said Friday the guidelines are part of an effort to reduce the likelihood of people contracting Ebola from corpses.

WHO Ebola expert Pierre Formenty says at least one in five infections occur during burials.

The guidelines give step-by-step advice to health workers for both Christian and Muslim burials.

See complete article
http://news.yahoo.com/un-releases-manual-safe-ebola-burials-154352654.html

See WHO manual

http://apps.who.int/iris/bitstream/10665/137379/1/WHO_EVD_GUIDANCE_Burials_14.2_eng.pdf?ua=1

http://www.who.int/csr/resources/publications/ebola/safe-burial-protocol/en/

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US Officials Unveil Plan to Test Ebola Drugs

NEW ORLEANS --The quest for an Ebola treatment is picking up speed. Federal officials have unveiled a plan to test multiple drugs at once, in an umbrella study with a single comparison group to give fast answers on what works.

"This is novel for us" and is an approach pioneered by cancer researchers, said Dr. Luciana Borio, head of the U.S. Food and Drug Administration's Ebola response. "We need to learn what helps and what hurts" and speed treatments to patients, she said.

She outlined the plan Wednesday at an American Society of Tropical Medicine and Hygiene conference in New Orleans....

Everyone in the umbrella study would get supportive care, such as intravenous fluids, then be assigned to receive one of several drugs or be in a comparison group. That's needed because without one, there's no way to know if any problems or deaths are from the drug or the disease, Cox said....

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New study sheds light on the importance of supportive care for Ebola patients

                                                                     Nov. 6, 2014

...a WHO-coordinated retrospective study, published in the New England Journal of Medicine, provides evidence that supportive care, especially rehydration and correction of metabolic abnormalities, may contribute to patient survival.

The study analysed clinical data on 37 confirmed Ebola patients admitted for treatment at hospitals in Conakry, Guinea’s capital and most densely populated city.

The cases occurred during the first month of West Africa’s first outbreak of Ebola virus disease. Fourteen of the patients were heath care workers. The majority (12) acquired their infection in a health care setting.

The majority (65%) of patients were male, countering assumptions that women, who are more likely to provide home care for patients and prepare bodies for funerals and burials, are more frequently exposed and infected.

To replace fluids lost through severe diarrhoea, 36 patients (97%) received oral rehydration solution. Additional intravenous fluid resuscitation was given to 28 (76%) patients.

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U.N. Ebola chief voices guarded optimism

ASSOCIATED PRESS                                   NOV. 7, 2014

UNITED NATIONS -- The U.N.'s Ebola chief said an extraordinary global response over the past month has made him hopeful the outbreak could end in 2015, though he cautioned that the fight to contain the disease is not even a quarter done.

"Until the last case of Ebola is under treatment, we have to stay on full alert," Dr. David Nabarro said Thursday in an interview with The Associated Press. "It's still bad."

Nabarro said a month ago that the number of Ebola cases was probably doubling every three-to-four weeks. He warned then that without a mass global mobilization, "the world will have to live with the Ebola virus forever" and that the response needed to be 20 times greater.

But in the past four weeks, the rate of Ebola infections seems to be slowing in some parts of West Africa, Nabarro said in the interview. In other hotspots, he said, it appears to be expanding the way it was a month ago.

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Experimental Ebola drugs should not be withheld, WHO says

World Health Organisation doubts feasibility of placebo-controlled trials in west Africa, but FDA favours ‘gold standard’

THE GUARDIAN                                                                                                           Nov. 6, 2014
By Sarah Bosley

Scientists involved in trials of experimental drug treatments for the Ebola epidemic in west Africa should not be compelled to withhold them from some patients, says the World Health Organisation, despite objections from the US that it is the only way to be sure they work.

Vials of the experimental VSE-EBOV vaccine for Ebola. Photograph: Mathilde Missioneiro/AP

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Ebola cases rise sharply in Sierra Leone

USA TODAY                                                Nov.6, 200r

by Liz Aazbo

Sierra Leone is reporting an alarming increase in the number of new Ebola cases, with 435 confirmed in the past week.

About 24% of the Ebola cases in Sierra Leone have been reported in the past three weeks, although the outbreak began in March, according to the World Health Organization.

Mothers wait inline for their children to be vaccinated by heath workers at the Pipeline Community Health Center, situated on the outskirts of Monrovia, Liberia. The Ebola outbreak has spawned hidden cases of malaria, pneumonia, typhoid and the like that are going untreated because people in the countries hardest hit by Ebola either cannot find an open clinic or are too afraid to go to one.(Photo: Abbas Dulleh, AP)

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Ebola crisis draining development budgets in West Africa, study finds

UNITED NATIONS DEVELOPMENT PROGRAMME                                              Nov. 5, 2014

New York  -- The Ebola outbreak in West Africa is impairing the ability of governments to raise revenues, increasing their exposure to domestic and foreign debts and may make them more dependent on aid, according to the latest study (PDF) on the socio-economic impact of the crisis carried out by the UN development agency.

Investments in kick-starting economies and long-term development urgently needed

“We need to make sure that the Ebola outbreak does not lead to socio-economic collapse,” said Abdoulaye Mar Dieye, the Director of the Regional Bureau for Africa at the United Nations Development Programme (UNDP). “This crisis is already taking a toll on budgets and reducing the governments’ policy leeway to make much-needed investments in critical areas such as health and education for their citizens.” He added that the effects of the Ebola crisis will last long after the epidemic is brought under control.

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Obama Seeks $6.2 Billion for Ebola Fight

UPDATE: Senate Appropriations schedules hearings for Wednesday, Nov. 12.

Moving quickly, the Senate Appropriation Committee announced it wil take up the administration's proposals at a hearng next Wednesday with a full slate of government officials from the key agencies. The committee will remaiend chaired bya  Democat, Senator Barbara Mikulski of Maryland, until the end of this Congressional session. The Republican controlled House Appropriations Committee has not yet announced hearings.

See Senate statement.

http://www.appropriations.senate.gov/news/chairwoman-mikulski-statement-funding-request-white-house-fight-ebola-here-and-abroad, 

Text of White House letter to Congress

http://www.whitehouse.gov/the-press-office/2014/11/05/letter-president-emergency-appropriations-request-ebola-fiscal-year-2015

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THE ASSOCIATED PRESS                                     Nov. 5, 2014

By JIM KUHNHENN and ANDREW TAYLOR

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