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In Ebola Outbreak, Bad Data Adds Another Problem

ASSOCIATED PRESS -By MARIA CHENG and SARAH DiLORENZO Dec. 14, 2014

LONDON--As health officials struggle to contain the world's biggest-ever Ebola outbreak, their efforts are being complicated by another problem: bad data.

Having accurate numbers about an outbreak is essential not only to provide a realistic picture of the epidemic, but to determine effective control strategies. Dr. Bruce Aylward, who is leading the World Health Organization's Ebola response, said it's crucial to track every single Ebola patient in West Africa to stop the outbreak and that serious gaps remain in their data.

"As we move into the stage of hunting down the virus instead of just slowing the exponential growth, having good data is going to be at the heart of this," Aylward said. "We are not there yet and this is something we definitely need to fix."

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Sierra Leone Baffled by Doctors' Ebola Deaths

VOICE OF AMERICA  by James Butty                             Dec. 8, 2014
FREETOWN --Sierra Leone’s chief medical officer has said he is baffled by the deaths of three doctors from Ebola over a three-day period.  

Dr. Brima Kargbo said a survey conducted jointly with the U.S. Centers for Disease Control (CDC) found that 70 percent of infections did not come from either the country’s Ebola holding centers or treatment facilities. 

FILE - A health worker prepares to disinfect a van used for burial purposes in Freetown, Sierra Leone.

Kargbo said Dr. Aiah Solomon Konoyeima died Saturday, becoming the 10th Sierra Leonean physician to die of the virus. 

“We have Dr. Tom Rogers and Dr. [Dauda] Koroma, who were buried yesterday, and also Dr. Konoyeima,” Dr. Kargbo said.

Rogers was a surgeon at the Connaught Hospital, the main referral unit in the capital, Freetown. He was reportedly being treated at the British-run Kerry Town Ebola treatment center. He was said to be responding well to treatment when his condition deteriorated dramatically on Friday.

Koroma died at the Hastings Treatment Center, which is run entirely by local Sierra Leone medics.

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As Ebola Rages, Poor Planning Thwarts Efforts

NEW YORK TIMES --by Jeffrey Gettleman                      Dec. 7, 2014

KERRY TOWN, Sierra Leone —On a freshly cleared hillside outside the capital, where the trees have been chopped down and replaced with acres of smooth gravel, the new Ebolatreatment center seems to have everything. There are racks of clean pink scrubs and white latex boots, bathrooms that smell like Ajax, solar-powered lights, a pharmacy tent, even a thatch-roofed hut to relax in.

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Doctors Try Survivors’ Blood to Treat Ebola

Clinical Trials Are Being Launched in Africa but Face Challenges in Designing Ethical Studies, Compensating Donors

WALL STREET JOURNAL                                                                                                    Dec. 5, 2014
by Betsy McKay in Atlanta, David Gauthier-Villars in Conakry, Guinea, and Patrick McGroarty in Monrovia, Liberia

...Nearly a year after Ebola began spreading in West Africa, and with a proven drug or vaccine still far off, researchers are launching clinical trials on a product at hand: the blood of survivors.

 They want to determine whether so-called convalescent plasma or serum, chock full of antibodies, can help fight off the disease. But they face a number of complexities in carrying out the trials, including persuading survivors to participate....

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Is Ebola Taking a Heavier Toll on Women?

VOICE OF AMERICA  by Carol Guensburg                                                                                 Dec. 5, 2014
The Ebola virus, indiscriminate and opportunistic, has infected more than 17,000 people in West Africa, the World Health Organization reports. But some observers fear the epidemic may be exacting an especially heavy toll on women and girls.    

Its impact goes well beyond the disease itself, amplifying females’ vulnerabilities, exploiting their limits within traditional societies, and motivating responses of strength and resilience.

Fatmata Sowa, 28, is among the few women who've joined the Red Cross safe and dignified burial teams in Sierra Leone. ( Lisa Pattison / IFRC)

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Ebola Free-for-All Could Trigger Bad Science and Wasted Efforts

Everybody and his uncle, it seems, has an idea of something that might work to cure people infected with the deadly virus

 SCIENTIFIC AMERICAN    By Helen Branswell                        Dec. 4, 2014

When it comes to treatments for Ebola, there has been a nearly four-decade-long drought. Nothing in the medical arsenal attacks the virus directly....

 

 

 

Dr. John M. Dye, Jr., U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) Viral Immunology branch chief, works in a laboratory at the USAMRIID headquarters in Frederick, Maryland. Dr. Dye is leading a team that is conducting a study with nonhuman primates involving the experimental drug ZMapp, an experimental treatment for Ebola patients. Credit: CDC

 

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Stricken with Ebola, a family runs away from treatment — and into the jungle

      

November 21, 2014 - A family behind a bright orange quarantine rope learns of the death of a family member.
Nikki Kahn/The Washington Post

WASHINGTON POST--by Kevin Sieff                                                                 Dec. 4, 2014
KOINADUGU, Sierra Leone --
...Six months after the world’s largest Ebola outbreak began, experts say one of their biggest challenges is persuading people to trust the medical system. Families still hide suspected Ebola victimsor refuse to take them to health facilities. The problem exists in Liberia, but some foreign health officials say it’s even more daunting in Sierra Leone, where the transmission rate continues to climb even as it declines in the neighboring country.

In rural areas like Koinadugu, a district bordering Guinea, the problem is especially severe. There is no electricity or running water, let alone a modern hospital. Medicine usually means local herbs, generic malaria pills or the advice of a local healer. People whisper that disinfectant spreads the disease rather than kills it.

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Sierra Leone widens Ebola quarantine

AFP                                                                                                          Dec. 2, 2014

FREETOWN -- Ebola-hit Sierra Leone has quarantined hundreds of thousands more citizens, it said Tuesday, sealing off a sixth district, with more than half of the country's population already under lockdown.

A nurse wearing personal protective equipment checks on a patient at the Kenama ebola treatment center run by the Red Cross Society on November 15, 2014 in Sierra Leone ©Francisco Leong (AFP/File)

Tonkolili, in the centre, was added to the growing list of districts which no one is allowed to leave or enter without special dispensation, in an effort to combat an outbreak which is spiralling out of control, with 1,400 deaths so far....

The northern districts of Port Loko and Bombali were closed off indefinitely along with the southern district of Moyamba in September -- effectively sealing in more than one million people.

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Five million children out of school in West Africa due to Ebola

REUTERS-by  Misha Hussain                                   Dec. 3, 2014

DAKAR, Senegal   - Some five million children are out of school in Guinea, Liberia and Sierra Leone because of the deadly Ebola outbreak, according to a report by the Global Business Coalition for Education.

A man walks by a mural with health instructions on treating the Ebola virus, in Monrovia, November 18, 2014. Credit: Reuters/James Giahyue

Schools and other public buildings have been closed because they are believed to increase the spread of the virus. Many are now used as holding centers for Ebola patients.

The report, co-written with A World at School, said being out of school can have a crippling impact on vulnerable children, especially girls, who are more likely to face high-risk situations as a result, including early marriage and pregnancy.

If schools are not reopened, the most vulnerable children will become trapped in a cycle of poverty with devastating consequences for their health and economic development, the report said.

Read complete story.

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Finding the Ebola virus’ vulnerable points

Three copies of the Ebola glycoprotein (blue) with antibodies (yellow) latched on to them. Picture by Stanfordby Shalini Saxena - Nov 30 2014 - http://arstechnica.com

We know what antibodies stop it in its tracks—we now know where they attach.

The latest Ebola outbreak has dwarfed any that have occurred since the discovery of the virus in 1976; previous outbreaks have had lethality rates of up to 90 percent. Yet no vaccines or therapies are currently approved for human use, which limits our ability to treat patients and contain the outbreak. Mixtures of monoclonal antibodies (see sidebar) are a potential treatment option that has been used experimentally.

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