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Broad Institute analyzes Ebola genomes

MIT THE TECH  by Jennifer F. Switzer                         Jan. 14, 2015

CAMBRIDGE , MA-- At the Broad Institute of MIT and Harvard, in a lab run by accomplished computational geneticist Pardis Sabeti ’97, researchers have collaborated with institutions in the U.S. and abroad to sequence and analyze more than 99 Ebola virus genomes collected by fellow scientists in Sierra Leone. They are on the lookout for mutations that could aid in developing new treatment options for Ebola, or that could serve as indications that the virus is evolving to become more deadly.

Contained within the virus’s 19,000 base-pair genome, the team has found more than 300 genetic changes that separate the 2014 Ebola virus from its predecessors. Of interest is one particular cluster of mutations which, having outlasted other genetic variations, could possibly be conferring some sort of genetic advantage to the virus ebola patients for sequencing.

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http://tech.mit.edu/V134/N62/ebola.htm

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In Africa, a Decline in New Ebola Cases Complicates Vaccine Development

NEW YORK TIMES      by Andrew Pollack                                                           Jan. 9, 2015

As authorities and drug companies hurriedly prepare to begin testing Ebola vaccines in West Africa, they are starting to contemplate a new challenge: whether an ebbing of the outbreak could make it more difficult to determine if the experimental vaccines are effective.

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Health 2 Leading Ebola Vaccines Appear Safe, Further Tests Starting

ASSOCIATED PRESS  by Maria Cheng                                                                          Jan. 9, 2015
LONDON --The World Health Organizationsays the two leading Ebola vaccines appear safe and will soon be tested in healthy volunteers in West Africa.

After an expert meeting this week, WHO said there is now enough information to conclude that the two most advanced Ebola vaccines ? one made by GlaxoSmithKline and the other licensed by Merck and NewLink ? have "an acceptable safety profile."

In a press briefing on Friday, Dr. Marie-Paule Kieny, who heads WHO's Ebola vaccine efforts, said "the cupboard (for Ebola vaccines) is filling up rapidly."

She said further trials in healthy people in West Africa, including health workers, are scheduled to start soon. Kieny added several other vaccines were being developed in the U.S., Russia and elsewhere.

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http://abcnews.go.com/Health/wireStory/leading-ebola-vaccines-safe-tests-starting-28107527

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J&J, Bavarian Nordic start clinical tests in Ebola vaccine race

REUTERS     by Ben Hirschler                              Jan. 6, 2015
LONDON --Johnson & Johnson has started clinical trials of its experimental Ebola vaccine, which uses a booster from Denmark's Bavarian Nordic, making it the third such shot to enter human testing.

The initiation of the Phase I study in Britain, which had been expected about now, marks further progress in the race to develop a vaccine against a disease that has killed more than 8,000 people in West Africa since last year.

Two other experimental vaccines, one from GlaxoSmithKline and a rival from NewLink and Merck, are already in clinical development. However, the J&J vaccine offers a different approach, since it involves two separate injections.

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http://www.reuters.com/article/2015/01/06/us-health-ebola-vaccine-j-j-idUSKBN0KF0HH20150106

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Ebola Doctors Are Divided on IV Therapy in Africa

NEW YORK TIMES  by Donald G. McNeil, Jr.                                                     Jan. 1, 2015

Medical experts seeking to stem the Ebola epidemic are sharply divided over whether most patients in West Africa should, or can, be given intravenous hydration, a therapy that is standard in developed countries. Some argue that more aggressive treatment with IV fluids is medically possible and a moral obligation. But others counsel caution, saying that pushing too hard would put overworked doctors and nurses in danger and that the treatment, if given carelessly, could even kill patients.

A nurse gave an Ebola patient intravenous fluids at the Red Cross treatment center in Kenema, Sierra Leone, in November. Credit Francisco Leong/Agence France-Presse — Getty Images

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Is Ebola Here to Stay?

SCIENTIFIC AMERICAN by Dina Fine Maron                                  Dec. 29, 2014
Kisses are at a premium in the capital of Liberia. Even a hug or a handshake between friends is often out of the question. That’s the new normal ever since Ebola began ravaging communities throughout Liberia, Sierra Leone and Guinea. For much of the past year, residents of these west African countries have wondered if daily life will ever be able to return to the way things once were.

Monrovia, Liberia - November 2014: Ebola survivor Korlia Bonarwolo leads a training of health workers at a mock Ebola Treatment Unit in Liberia. "I think with the knowledge we have now, the treatment is going to be much greater," he says.

Photo: Morgana Wingard/Sarah Grile, 2014

And at the heart of the matter is a scientific question: has Ebola now found a permanent foothold among humans?

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Experts call for faster mobilisation of “overlooked” survivors to contain Ebola epidemic

OXFORD UNIVERSITY PRESS                                                                                  Dec, 10, 2014

In an editorial published online today in the International Journal of Epidemiology, experts from the Departments of Psychiatry and Epidemiology at Columbia University, New York, are calling for survivors of the Ebola epidemic to be mobilised in a bid to hasten containment of the disease.

We already know that the current Ebola outbreak is unique in its magnitude and for its dispersion in dense, mobile populations. Physicians and nurses face high mortality, and foreign aid in the form of medical supplies and staff continues to be unequal to the scope of the problem. With a case recovery rate of around 30% at the present time in West Africa, survivors already number in the thousands.

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WHO: malaria gains 'at risk' in Ebola-affected countries

MEDICAL NEWS TODAY                                                                                                 Dec. 9, 2014

LONDON --Thanks to increased disease control, global deaths to malaria have fallen dramatically, and the number of new cases is steadily declining, say the World Health Organization in a new report. Also, an increasing number of countries are moving toward eliminating the mosquito-borne disease altogether. But the UN agency warns these gains are fragile, and no more so than in countries worse-affected by the Ebola crisis.

 
A new report from the World Health Organization says the number of lives claimed by malaria worldwide fell by 47% between 2000 and 2013, and by 54% in Africa, where the vast majority of deaths occur.

The 2014 World Health Organization (WHO) report says deaths to malaria worldwide fell by 47% between 2000 and 2013. In the WHO African Region, where 90% of deaths to malaria occur, the reduction is 54%.

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Rapid Ebola test is focus of NIH grant to Rutgers scientist

REPORTS Of RESEARCH ON TWO METHODS OF RAPID TESTING FOR EBOLA

(Two items, scroll down)

MEDICAL PRESS                                                                                     Dec. 8, 2014

Rutgers researcher David Alland, working with the California biotechnology company Cepheid, has received a grant of nearly $640,000 from the National Institutes of Health to develop a rapid test to diagnose Ebola as well as other viruses that can cause symptoms similar to Ebola.

Researchers will adapt this cartridge, now used worldwide for tuberculosis screenings, to collect and test samples from potential Ebola patients. Credit: John Emerson

Alland, a professor of medicine and associate dean for clinical research at Rutgers New Jersey Medical School and the principal investigator of the project, says would be able to take the test to small villages and other remote locations where the spread of Ebola has been especially rampant and diagnose patients where they live...

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Number of Ebola deaths could be cut by use of basic measures, say experts

THE GUARDIAN  by in Freetown and
Dec. 5, 2014

Basic medical interventions such as giving Ebola patients rehydration salts and fluids from bigger bags could cut the death toll in west Africa in the absence of a proven cure, experts in tropical diseases write on Friday in the Lancet.

The doctors say it is “therapeutic nihilism” to assume there is no treatment for Ebola just because there are no drugs. It is likely, they say, that many patients die because of dehydration.

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