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Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak

Antibodies targeting the Ebola virus surface glycoprotein (EBOV GP) are implicated in protection against lethal disease, but the characteristics of the human antibody response to EBOV GP remain poorly understood. We isolated and characterized 349 GP-specific monoclonal antibodies (mAbs) from the peripheral B cells of a convalescent donor who survived the 2014 EBOV Zaire outbreak. Remarkably, 77% of the mAbs neutralize live EBOV, and several mAbs exhibit unprecedented potency. Structures of selected mAbs in complex with GP reveal a site of vulnerability located in the GP stalk region proximal to the viral membrane. Neutralizing antibodies (NAbs) targeting this site show potent therapeutic efficacy against lethal EBOV challenge in mice. The results provide a framework for the design of new EBOV vaccine candidates and immunotherapies.

(complet article)

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WHO statement on end of Ebola flare-up in Sierra Leone

WHO joins the government of Sierra Leone in marking the end of the recent flare-up of Ebola virus disease in the country. As of today, 17 March, 42 days have passed, two incubation cycles of the virus, since the last person confirmed to have Ebola virus disease in the country tested negative for a second time.

This latest flare-up of Ebola brings to 3 590 the number of lives lost in Sierra Leone to an epidemic that devastated families and communities across the country and disrupted every aspect of life.

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MOE/EDSA visits R&E Project Sites

Ministry of Energy in collaboration with the Electricity Distribution and Supply Authority (EDSA) has in last 3 weeks, visited the Reinforcement & Extension (R&E) of distribution network project sites. The visit was to see progress contractors have made since the project commenced in October 2015.


The R&E of low-medium voltage distribution network for Western Area is a government project which is funded by Islamic Development Bank IDB. The project will address low voltage and poor cable connections by improving on and extending the existing network.

 

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Ministry of Energy Empowers Technical Engineers

The Ministry of Energy with a Vision to build the capacity of the nation’s young Engineers has funded a comprehensive external training through SALINI for the country’s electro-mechanic engineers in Hydropower operations and maintenance.


Chairing the farewell meeting the Ministry organized for the 9 Hydropower Engineers on Monday 14th March 2016 at the Minister’s office in Freetown, Permanent secretary Zainab Buya-Kamara was quick to caution the trainees that the golden opportunity given to them must be judiciously utilized. She continued that the Engineers would have to write individual reports and certificates will be given based on merit. The blunt Permanent secretary even ended that a clause would be signed between the Ministry and the Engineers for the training and for them to come back and serve the nation for some time.

 

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Evaluation of a National Call Center and a Local Alerts System for Detection of New Cases of Ebola Virus Disease — Guinea, 2014–2015

The epidemic of Ebola virus disease (Ebola) in West Africa began in Guinea in late 2013 (1), and on August 8, 2014, the World Health Organization (WHO) declared the epidemic a Public Health Emergency of International Concern (2). Guinea was declared Ebola-free on December 29, 2015, and is under a 90 day period of enhanced surveillance, following 3,351 confirmed and 453 probable cases of Ebola and 2,536 deaths (3). Passive surveillance for Ebola in Guinea has been conducted principally through the use of a telephone alert system.

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How Digital Health is Opening Up Communication Between Doctors & Patients

Nothing is more important between a doctor and a patient than communication. The more you communicate, the healthier people get and the more knowledgeable doctors become. Without open lines of communication, important details can be missed, patients might put off appointments for too long and trust can’t be built.

Cloud-based patient relationship management (PRM) systems are one of the latest ways for offices and clinics to keep the lines of communication open. This new digital health technology is providing avenues for two-way communication that makes discussions between doctors and patients easier to initiate, monitor and document.

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