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Clinical care for survivors of Ebola virus disease

Background

The outbreak of Ebola virus disease (EVD) that began in 2013 in West Africa had by December 2015, resulted in over 28,000 cases. Although estimates of the number of people affected during the outbreak vary, up to 10,000 EVD survivors may require convalescent care. A number of both short- and long-term medical problems have been reported in EVD survivors, including mental health issues for both survivors and other family and community members (1-19). In addition, increasing recognition that Ebola virus may persist in selected body compartments of EVD survivors, most notably in the semen of males, brings awareness of the possibility of reintroduction of the virus in areas where transmission has previously been eliminated. EVD survivors need comprehensive support for the medical and psychosocial challenges they face and also to minimize the risk of continued Ebola virus transmission, especially from sexual transmission. This document provides guidance on providing the necessary care and services for clinical care and virus testing, and should be used to guide the planning and delivery of ongoing health services to people who have recovered from EVD. 

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Over 170 Children Fed By Ripsa Culture Gedo, Hope 4 Ebola Orphans

Two Diaspora led organizations including Ripsta Culture GEDO, Hope 4 Ebola Orphans and their partners Embracing children Adoption Services USA have fed over 170 children in Mabrown, Newton Community.

Photo of children during the meal event at Mabrown Village

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Post-Ebola survivors hit by brain health issues - study

A majority of Ebola survivors suffer some form of long-term brain health problems, according to a new study.

Patients who were successfully treated for the disease were found to have neurological issues six months later.

The most common problems included muscle pain, headaches, memory loss and depressed moods, but in rare cases patients were suicidal, the US researchers said.

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Ebola: Sierra Leone's survivors return to daily life – but as outcasts

When Abibatu and Lanphia finally returned home from the field treatment centre where they came close to losing their lives to Ebola, they hoped it was an end to the terrible price that the virus which had robbed them of their father and two brothers had exacted from their family.

Instead, what awaited them was a second battle for survival against the disease – this time the struggle against stigmatisation and rejection by a community which blamed them for bringing the disease into their midst in Sierra Leone and sought turn them into outcasts.

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How youth triumphed in the disaster ebola

Two years after the outbreak of Ebola in West Africa, Kamanda Kamara, committee member youth advisers Plan International Sierra Leone, published on his blog about the participation of people in the battle to contain the virus and how their work has contributed to change in communities. "It is important to continue working and investing funds in structural reforms to strengthen health systems," said Concha Lopez, CEO of Plan International Spain.

 

During the outbreak of ebola I saw many people infected and even die in my community. I thought it was, somehow, help save my community and end this terrible disease.

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Low-cost portable device that can detect Ebola

Researchers have developed a low-cost and portable diagnostic device that can be used to detect Ebola infection and many other diseases. The device could be particularly useful to monitor endemic, epidemic and pandemic disease outbreaks in resource-limited developing countries that need portable diagnostic equipment that functions outside the hospital.

Read more at: http://www.oneindia.com/international/low-cost-portable-device-that-can-detect-ebola-2020618.html

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Ebola crisis provides framework for responding to outbreaks like Zika virus

As world leaders grapple with containing the Zika virus, the Ebola epidemic in West Africa provides valuable lessons for how to respond to other infectious disease epidemics, according to a policy report published by researchers at Princeton University and the Wellcome Trust.  

Rebuilding local health care infrastructures, improving capacity to respond more quickly to outbreaks and considering multiple perspectives across disciplines during decision-making processes are among the key recommendations the authors propose. 

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Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak

Antibodies targeting the Ebola virus surface glycoprotein (EBOV GP) are implicated in protection against lethal disease, but the characteristics of the human antibody response to EBOV GP remain poorly understood. We isolated and characterized 349 GP-specific monoclonal antibodies (mAbs) from the peripheral B cells of a convalescent donor who survived the 2014 EBOV Zaire outbreak. Remarkably, 77% of the mAbs neutralize live EBOV, and several mAbs exhibit unprecedented potency. Structures of selected mAbs in complex with GP reveal a site of vulnerability located in the GP stalk region proximal to the viral membrane. Neutralizing antibodies (NAbs) targeting this site show potent therapeutic efficacy against lethal EBOV challenge in mice. The results provide a framework for the design of new EBOV vaccine candidates and immunotherapies.

(complet article)

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Two Ebola deaths and three suspected cases in Guinea 'flare-up'

World Health Organisation had just announced ‘milestone’ of no new infections in neighbouring Sierra Leone when latest fatalities came to light

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WHO statement on end of Ebola flare-up in Sierra Leone

WHO joins the government of Sierra Leone in marking the end of the recent flare-up of Ebola virus disease in the country. As of today, 17 March, 42 days have passed, two incubation cycles of the virus, since the last person confirmed to have Ebola virus disease in the country tested negative for a second time.

This latest flare-up of Ebola brings to 3 590 the number of lives lost in Sierra Leone to an epidemic that devastated families and communities across the country and disrupted every aspect of life.

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