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Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak

Antibodies targeting the Ebola virus surface glycoprotein (EBOV GP) are implicated in protection against lethal disease, but the characteristics of the human antibody response to EBOV GP remain poorly understood. We isolated and characterized 349 GP-specific monoclonal antibodies (mAbs) from the peripheral B cells of a convalescent donor who survived the 2014 EBOV Zaire outbreak. Remarkably, 77% of the mAbs neutralize live EBOV, and several mAbs exhibit unprecedented potency. Structures of selected mAbs in complex with GP reveal a site of vulnerability located in the GP stalk region proximal to the viral membrane. Neutralizing antibodies (NAbs) targeting this site show potent therapeutic efficacy against lethal EBOV challenge in mice. The results provide a framework for the design of new EBOV vaccine candidates and immunotherapies.

(complet article)

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How Digital Health is Opening Up Communication Between Doctors & Patients

Nothing is more important between a doctor and a patient than communication. The more you communicate, the healthier people get and the more knowledgeable doctors become. Without open lines of communication, important details can be missed, patients might put off appointments for too long and trust can’t be built.

Cloud-based patient relationship management (PRM) systems are one of the latest ways for offices and clinics to keep the lines of communication open. This new digital health technology is providing avenues for two-way communication that makes discussions between doctors and patients easier to initiate, monitor and document.

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Health Poverty Action upgrades 2 PHUs in Bombali

People of Tambakha and Magbaimba N’dowahun Chiefdoms were in jubilant mood last Saturday, 12th March 2016 when Health Poverty Action (HPA) handed over to the Ministry of Health and Sanitation two upgraded BIMOC health centres.

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Researchers conduct study of Ebola survivors in Sierra Leone

Researchers from the University's Institute of Translational Medicine have conducted a study of Ebola survivors to describe the medical problems they continue to have after recovering from the acute disease. The results of which have been published in the journal Emerging Infectious Diseases.

This week it was widely reported that a British Nurse, Pauline Cafferkey, who was thought to have made a full recovery from Ebola, has been taken to a hospital for a third time due to what health officials described as delayed complications from the virus -- raising further questions about the long-term impact of the disease on survivors. Cafferkey is one of thousands of survivors who have reported suffering from issues that appear to be related to late effects of the virus.

Symptoms persisting

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Treating Ebola with Plasma

During the Ebola outbreak of 1995 in the Democratic Republic of Congo, eight patients with Ebola were given blood transfusions from people who had recently recovered from Ebola. Seven of them survived.

The blood of people who have recently recovered from an infection contains antibodies that the body develops naturally to fight that infection. The transfusion of these antibodies into infected individuals (as whole blood, plasma, or concentrated antibodies) has a long history and has been proposed as a possible treatment for Ebola virus disease.

see more at: http://www.dddmag.com/news/2016/03/treating-ebola-plasma

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DFID makes the right noises over Ebola lessons

 

The outbreak of Ebola that devastated West Africa is out of the media spotlight, and no doubt many of us have wondered what happened to all those debates over lessons to be learned. A panel discussion at the United Kingdom’s Parliament delved into this issue last week.   The event was organised by the Africa All Party Parliamentary Group to launch a report reviewing evidence submitted in response to an inquiry into the Ebola response last year, which included our Spotlight collection.

See more at: http://www.scidev.net/global/ebola/scidev-net-at-large/dfid-ebola-disease-lessons-West-Africa.html#sthash.u9tzVGfh.dpuf

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Sierra Leone targets 1.5m children in measles campaign

The Second round of vaccination against measles in Sierra Leone has been scheduled to commence on Thursday, the Ministry of Health and Sanitation said today. Over 1.5 million children are being targeted during the five-day campaign that will see health volunteers move door-to-door to vaccinate children against the preventable viral disease that reared its ugly head at the height of the Ebola epidemic.

Children who missed out on other routine vaccinations will also be given those doses.

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Experimental Ebola treatment trial shows inconclusive results

Scientists recently conducted a trial for an experimental Ebola treatment in Guinea during the latest Ebola outbreak, hoping to gather information for future treatments and vaccines for Ebola.

 

Unfortunately, there is still no effective treatment for Ebola. The outbreak reached its height in September 2014, when the World Health Organization published a shot list of treatments that might fight the virus.

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